Our Mission
The Ishii Laboratory at Weill Cornell Medical College is interested in understanding the bidirectional relationship between brain function and systemic metabolism with an emphasis on metabolic deficits in Alzheimer’s disease and how it differs from normal aging. Our laboratory focuses on generating hypotheses derived from open questions in clinical neurology and neuroendocrinology, testing these hypotheses using molecular genetics and neuroscience techniques in the research laboratory, and whenever possible verifying these findings in human research studies.
Figure 1: The relationship between body weight/adiposity and age-related dementia (Adapted from Ishii and Iadecola, Biochimica et Biophysica Acta Molecular Basis of Disease 2016)